Chair of Biochemistry
    Prof. Dr. Aladár Szalay

    Prof. Dr. Aladár Szalay

     
    Phone:
         +49 931 - 31 84410
     
     
    E-mail:

         szalay@biozentrum.uni-wuerzburg.de


    Room:
        
    B110a

      


      

    Curriculum vitae

    Name

    Prof. Dr. Aladár Szalay

     

    Position

    Professor

    Affiliation

     

    Chair of Biochemistry, Theodor-Boveri-Institute at the Biocentre
    University of Würzburg
    Am Hubland
    97074 Würzburg
    Phone +49 931 - 31 84010

     

    szalay@biozentrum.uni-wuerzburg.de

     

     

     

     

     

     

     

     

     

    Career

    1966

    M.S. Biochemistry, Institute of Biochemistry, Martin Luther University, Halle/Saale, Germany

     

    1971

    Ph.D. Biochemistry, January 1971, Institute of Biochemistry, Martin Luther University, Halle/Saale, Germany

     

    1972-1973

    Research Scientist, Biological Res. Center Hungarian Academy of Sciences Szeged, Hungary

     

    1973-1975

    Gosney Research Fellow, California Institute of Technology Pasadena, CA, USA

     

    1975-1977

    Research Associate, California Institute of Technology Pasadena, CA, USA

     

    1962-1977

    Adjunct Professor, Division of Biological Sciences, Cornell University, Ithaca, New York, USA

    1977-1988 Associate Biochemistry Group Leader in Molecular Biology, Boyce Thompson Institute, Cornell University Ithaca, NY, USA
    1988-1995 Endowed Chair Professor, University of Alberta Edmonton, Alberta, Canada
    1993-1998 Professor of Microbiology and Molecular Genetics, Director of Molecular Biology and Gene Therapy Center, School of Medicine, Loma Linda University, Loma Linda, CA, USA
    1998-2003 University Professor of Biochemistry, School of Medicine Loma Linda University, Loma Linda, CA, USA
    since 2001 President & CEO, Chairman of the Board of Directors, Founder Genelux Corporation, San Diego, CA, USA
    since 2003 University Professor, Virchow Center for Experimental Biomedicine, Institute for Biochemistry and Institute for Molecular Infection Biology, University of Würzburg, Germany

     

    since 2009

    Professor, Department of Radiation Oncology, Rebecca and John Moores Comprehensive Cancer Center, University of California, San Diego, CA, USA

     

     

     

     

     

     

    Research Fields

     

    luciferase and fluorescent proteins
    tumor colonizing microorganisms for diagnosis and therapy

     

     

    Selected Awards

    1960-1972: Fellowship of Hungary (Distinguished Undergraduate Fellowship of Hungary)
    1962-1966: Foreign Undergraduate Fellowship, Ministry of Culture of Hungary
    1966-1971: Graduate Student Fellowship in Biochemistry, Awarded by the Hungarian National Academy of Sciences
    1973-1975: Gosney Award, California Institute of Technology, Pasadena, CA
    1985: Theobald Smith medal awarded by Squibb, Merck Corp. and Princeton University
    1985: Alexander von Humboldt Scholar Award, Max Planck Institut, Cologne, Germany
    1989: Award of the Economic Council of Advanced Technology, Edmonton, Canada
    1993: Wilhelm Exner Award – Vienna, Austria (Medal for Excellence in Science)
    1999: Alexander von Humboldt Prize, Bonn, Germany
    2002-2004: Vice President of International Society for Bioluminescence and Chemiluminescence
    2004-2006: President of International Society for Bioluminescence and Chemiluminescence

      

      

      

      

      


     

    Selected Publications

      

    Haddad D, Chen NG, Zhang Q, Chen CH, Yu YA, Gonzalez L, Carpenter SG, Carson J, Au J, Mittra A, Gonen M, Zanzonico PB, Fong Y, Szalay AA (2011): Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus. J Transl Med 9: 36.

    Frentzen A, Yu YA, Chen N, Zhang Q, Weibel S, Raab V and Szalay AA (2009): Anti-VEGF single chain antibody GLAF-1 encoded by oncolytic vaccinia virus significantly enhances therapy in colonized tumor xenografts. PNAS 106: 12915-20.

    Brader P, Stritzker J, Riedl CC, Zanzonico P, Cai S, Burnazi EM, Ghani ER, Hricak H, Szalay AA, Fong Y and Blasberg R (2008): Escherichia coli Nissle 1917 facilitates tumor detection by positron emission tomography and optical imaging. Clin Cancer Res 14(8): 2295-302.

    Weibel S, Stritzker J, Eck M, Goebel W and Szalay AA (2008): Colonization of experimental murine breast tumours by Escherichia coli K-12 significantly alters the tumour microenvironment. Cell Microbiol 10(6): 1235-48.

    Yu YA, Shabahang S, Timiryasova TM, Zhang Q, Beltz R, Gentschev I, Goebel W and Szalay AA (2004): Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins. Nat Biotechnol 22(3): 313-20.

    Dietrich G, Bubert A, Gentschev I, Sokolovic Z, Simm A, Catic A, Kaufmann SH, Hess J, Szalay AA and Goebel W (1998): Delivery of antigen-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide Listeria monocytogenes. Nat Biotechnol 16(2): 181-5.

    Escher A, O'Kane DJ, Lee J and Szalay AA (1989): Bacterial luciferase alpha beta fusion protein is fully active as a monomer and highly sensitive in vivo to elevated temperature. Proc Natl Acad Sci USA 86(17): 6528-32.

     

     

    Kontakt

    Lehrstuhl für Biochemie
    Am Hubland
    97074 Würzburg

    Tel.: +49 931 31-84026
    Fax: +49 931 31-84028
    E-Mail

    Suche Ansprechpartner

    Hubland Süd, Geb. B1 Hubland Nord, Geb. 32 Julius-von-Sachs-Platz 2 Fabrikschleichach Hubland Süd, Geb. B2 Campus Medizin